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Oxidative Stress’s Impact on the Body and How Ozone Can Help

Oxidative Stress is a major contributor to why we age, why our cells and tissue functions are restrictive, why our immune systems are suppressed, why many genetic predispositions can activate and “turn on,” and why many foreign pathogens can enter our bodies and thrive. Almost all degenerative diseases have a link to oxidative stress.

It is important to know that oxidative stress is a result of an imbalance between the production of free radicals and the body’s ability to detoxify or repair the damage caused by these unstable molecules.

The good news is that there are ways to help combat oxidative stress and chronic illness through lifestyle choices, antioxidant-rich foods, and supplements.

Some lifestyle changes that can help reduce oxidative stress include:

-eating a healthy diet

-exercising regularly

-avoiding tobacco smoke

-limiting alcohol intake

-maintaining a healthy weight

-managing stress

-getting enough sleep

-ozone therapy

By making some lifestyle changes and incorporating antioxidant-rich foods into your diet, you can help reduce your risk of chronic illness and improve your overall health. The biggest support we’ve seen is ozone therapy,

Ozone has been shown to be a powerful oxidant, and ozone therapy can help reduce oxidative stress by helping to detoxify the body and repair damaged cells. Ozone therapy can also help improve immune function and reduce inflammation, getting you back on the path to healing.

What is Ozone?

Ozone is an activated form of oxygen that can help to reverse oxidative stress by increasing the production of redox signaling molecules such as Nitric Oxide. Ozone also helps to kill pathogens, parasites, bacteria, fungus, and viruses.

If you suffer from a chronic illness, ozone therapy can be a helpful treatment option. Ozone therapy can help to support your immune system and kill pathogens that may be contributing to your illness.

Ozone therapy is an up-and-coming form of alternative or adjunctive medical treatment that is being used more and more to treat chronic illness, heavy metals, parasites, infectious diseases like Lyme and co-infections, and more. Many choose ozone therapy for its ability to help the body fight infection, boost the immune system, and reduce inflammatory processes.

Ozone therapy has been shown to be effective in treating a variety of conditions, including chronic fatigue syndrome, Lyme disease, multiple sclerosis, fibromyalgia, and arthritis. In addition, ozone therapy is also being studied as a potential treatment for cancer. There are many studies and trials to support both its effectiveness and safety, with one of the only downsides being cost and accessibility.

What are the Benefits of Ozone Therapy?

Why would you use ozone therapy for chronic illness? There are many benefits that can be achieved that cannot be accomplished with conventional treatments.

  1. The first benefit of ozone therapy for illness is its ability to help the body fight infection. Ozone therapy works by increasing the amount of oxygen in the blood, which helps to kill viruses and bacteria. In addition, ozone therapy can also help to boost the immune system and reduce inflammation.

  2. Many with chronic conditions struggle with severe fatigue, and ozone can help increase energy levels. Many people who suffer from chronic fatigue syndrome or other chronic illnesses find that ozone therapy helps them to feel more energetic.
  3. The third benefit of ozone therapy is its ability to reduce pain. Ozone therapy can help to reduce inflammation, which can lead to pain relief, even for those with systemic or idiopathic.

  4. Brain fog or trouble thinking? Ozone can not only improve cognitive function, but it can also support degenerative neurological conditions. Many people who suffer from conditions like dementia or Alzheimer's disease find that ozone therapy helps them to think more clearly and remember things better, but it can help those who need any type of brain support.

  5. The fifth benefit of ozone therapy is its ability to improve circulation. Ozone therapy can help to increase blood flow and oxygenation to the tissues, which can help to improve overall health.

  6. Ozone therapy can detoxify the body. Ozone therapy can help to remove toxins from the body, which can improve overall health and well-being.

  7. Ozone can be used topically as well to improve the appearance of the skin, with a product like the Ozone Bubbler. Ozone therapy can help to increase collagen production, which can help to reduce wrinkles and improve the overall appearance of the skin.

  8. Feeling overwhelmed and need to relieve stress? Ozone can help with that, too. Ozone therapy can help to relax the mind and body, which can be a great benefit to anyone dealing with chronic conditions. It can also help improve sleep with increased oxygen levels.

Ozone therapy is a safe and effective alternative or adjunctive medical treatment for chronic illness, infectious disease, and cancer. If you are interested in ozone therapy, be sure to talk to your practitioner about whether it is right for you.

How Does Ozone Work?

Ozonated autohemotherapy has been around for many years, since the 1970s. As technology advanced and medical professionals could accurately read concentrations of ozone with photometers, this therapy became even more widely used and popular.

Ozone therapy is a form of oxygen therapy that uses ozone, a gas that is made up of three oxygen atoms. When ozone is used therapeutically, it is mixed with pure oxygen and then administered to the patient either through inhalation, injection (including intramuscular), or topical application.

Oxygen can equilibrate with water extracellularly and within the red blood cells to bind to hemoglobin, increasing pO2 until fully oxygenated. Ozone is also ten times more hydrosoluble than oxygen, meaning it can mix easily into aqueous plasma.

Ozone treatment specifically affected the activation of certain genes: HIF-1a, NFAT, and the Nrf2 pathways, which upregulate antioxidants and help suppress inflammation.

There’s a lot of science behind the mechanism of action, as explained in this excerpt from Medical Gas Research: “Ozone therapy may activate Nrf2 via moderate oxidative stress, and suppress NFκB and inflammatory responses. Mild immune responses are induced via other nuclear transcriptional factors, such as nuclear factor of activated T-cells (NFAT) and activated protein-1 (AP-1). Further researches able to elucidate whether the mechanisms of action of ozone therapy involve nuclear transcription factors, such as Nrf2, NFAT, AP-1, and HIF-1α are warranted.”


Ozone can also activate glycolysis (which breaks down glucose and turns it into energy) and boost adenosine triphosphate (ATP) (which captures energy and transfers it to other cellular processes). Both of these can ameliorate feelings of tiredness and fatigue.

Ozone increases the production of redox signaling molecules, which include Reactive Oxygen Species like nitric oxide, superoxide, hydrogen peroxide, peroxynitrite, and hydroxyl radical. Redox signaling molecules are important for a number of reasons, but one of the most important is that they help to control inflammation in the body.

This is why ozone can be beneficial for chronic illnesses that stem from or create inflammation (for example, mycotoxins in mold toxicity or by-products of die-off with Lyme disease or other pathogens).

What are the different types of ozone?

There are three main types of ozone: medical ozone, therapeutic ozone, and ozonated water.

Medical ozone is ozone that is used for medical purposes as a type of oxygen therapy to increase the amount of oxygen in the blood. This is the main form with published studies and clinical trials backing its effectiveness.

Therapeutic ozone is ozone that is used for therapeutic purposes, like ozone saunas or ozone steam rooms. Ozonated water is water that has been infused with ozone gas. Ozonated water can be used topically or ingested, and it has a variety of benefits, including the ability to fight infection, boost the immune system, and reduce inflammation.

Ozone can be used in a bath or to clean your fruits and vegetables. You can also drink ozone-infused water.

How Often Should You Use Ozone?

The frequency of ozone therapy depends on the condition being treated and the severity of the condition. In general, ozone therapy is usually done once or twice a week for acute conditions and three to four times a week for chronic conditions. Please see a qualified practitioner whenever making any changes to your healing protocol.

Therapeutic ozone is ozone that is used for therapeutic purposes. Ozonated water is water that has been infused with ozone gas, which is used for drinking or topical application.

What are the Benefits of Ozone Therapy for Chronic Illness and Healing?

Oxygen is important to the body in a number of ways. One of the most important is that it helps to control inflammation. Inflammation is a normal response by our bodies to injury or infection. However, chronic inflammation can contribute to a number of diseases and conditions.

Ozone is used in dentistry, skin diseases, for COVID treatment, fibromyalgia, and many chronic illnesses.

Infectious Disease/Lyme

Ozone also helps to kill pathogens, parasites, bacteria, fungus, and viruses. This is important because these organisms can contribute to chronic illness. By killing these organisms, ozone therapy can help to support your immune system and improve your overall health.

Lyme Disease is difficult to diagnose and even more difficult to treat, with conventional medicine only recognizing certain strains with outdated testing and a minimal antibiotic course of treatment (typically Doxycycline for 21 days). It’s much more complex than that, as Lyme often comes hand-in-hand with co-infections like Bartonella, Babesia, Rocky Mountain Spotted Fever, or Ehrlichiosis; heavy metals; parasites; viruses; and more. With tick-borne infections on the rise, more practitioners are turning to ozone therapy as an adjunctive treatment for Lyme and other infectious diseases like Ebola, or difficult-to-treat superbugs. Ozone acts as a germicide, showing positive responses to bacteria and viruses when administered with regularity.

Acute Bacterial Infections

Another use case for ozone is for acute bacterial infections, especially with the rise of antibiotic resistance. In a case of tick bite cellulitis, ozone was administered to help modulate the immune system and improve circulation, as well as fight against bacteria, pathogens, and other viruses on the topical wound. The wound responded quickly and fully resolved in 48 hours.



Fibromyalgia is a chronic disorder that causes widespread musculoskeletal pain, as well as fatigue and other symptoms. Fibromyalgia is characterized by tender points on the body, which are areas of pain and tenderness that occur in specific locations. People with fibromyalgia often have difficulty sleeping and may wake up feeling tired. While the exact cause of fibromyalgia is unknown, it is thought to involve changes in the way the nervous system processes pain signals, caused by a combination of genetic and environmental factors.

One study showed that 50% of symptoms improved in 70% of patients with ozone therapy, with NO reported side effects, making it a safe complementary therapy.


Complex Regional Pain Syndrome

Complex regional pain syndrome (CRPS) is a complex and debilitating condition that can cause severe pain, disability, and emotional distress. CRPS is thought to be caused by a problem with the nervous system. It often starts after an injury, surgery, or stroke. Symptoms can include severe pain, swelling, skin changes, and problems with movement.

There is some evidence that ozone therapy may be effective in treating complex regional pain syndrome. A small study published in the journal Pain found that ozone therapy was associated with a significant reduction in pain and an improvement in quality of life in people with CRPS.

In the Current Pain and Headaches Report, ozone therapy also helped improve low oxygen, inflammatory markers in the blood, and even signs of infection. One patient with pseudoseizures and dystrophy had no symptoms remaining after 120 sessions.


More than 29 million Americans have diabetes, and it's estimated that one in four adults have the disease but don't know it. A number of studies have shown that ozone therapy can help to improve the symptoms of diabetes. In one study, ozone therapy was found to be effective in treating diabetes-related nerve pain. In another study, ozone therapy was found to be effective in treating diabetes-related kidney damage.



Ozone therapy can be useful for supportive therapy across various types of cancer, including lung cancer, colon cancer, breast cancer, prostate cancer, melanoma, and renal cancer. One study out of the Mede Clinic in Italy followed 50 patients who were treated with a specific type of ozone therapy via autohemotherapy, per standards determined by the Scientific Society of Oxygen Ozone Therapy, starting twice a week for a month, then every other week. The patients were in different phases of their treatment, either actively being treated, had just finished treatment, or were in long-term palliative care. No side effects were reported and 70% of patients found symptoms to improve by at least 50%.


Postviral Recovery

Ozone has been an area of study for post-SARS-CoV2 infection, as many are reporting post-COVID symptoms spanning nearly all of the organs and body systems: fatigue, pain, digestive issues, heart palpitations, brain fog, anxiety, etc. 100 patients who had tested positive for COVID-19 received oxygen-ozone autohemotherapy (O2-O3-AHT) as dictated by a SIOOT protocol. These patients self-rated their fatigue before and after treatment. 67% had improvement in energy on this Fatigue Severity Scale.


Postoperative Care

Post-operation is a time when the body needs a bit of extra attention and care, and ozone therapy can help. It has been used to boost recovery in various types of surgeries, including spinal, knee, tumor removal, and much more. Ozone can help to improve the post-operative recovery time and also support against infection of any open wounds.


Water Treatment

Finally, ozone is useful in cases where food and water may not be clean enough to consume or bathe in. Waterborne diseases are on the rise, with Giardia and Cryptosporidium becoming more and more common in Functional Medicine patients. Ozone can disinfect and change the chemistry of water to help remove pathogens, glyphosate, and other chemicals… even viruses! There are a few at-home ozone bubblers on the marker to help keep you and your family healthier.


How Do I Use Ozone at Home?

If you’re looking for a safe, easy, and effective way to introduce ozone therapy right at home, we have two options.

TheraO3: Bubbler Ozone Generator

The TheraO3 Bubbler has a special tungsten mechanism that can sanitize all of your food. Fill your kitchen sink with tap water and use the bubbling device to add low Gamma O3 to the water to sanitize any fruits, vegetables, or other washable foods from bacteria, viruses, parasites, and other toxins.

Alternately, you can use this product to take an ozonated bath right from home, as well. This can support blood oxygen levels, lower oxidative stress, and even help support skin health. This can be used in tandem with Epsom salt soaks for an added layer of detoxification.


TheraO3 Ozone Module

If you’re a fan of infrared saunas, you can add the TheraO3 Ozone Module to your sauna session to create absorption of ozone through your skin, which will support an increase in blood oxygen levels. This may enhance immune function, create clear skin, support hair and nail growth, and create an inhospitable environment for parasites and pathogens. If you’re looking for a way to uplevel some of your lifestyle and detoxification tools, then this is a great step to oxygenate your body, which in turn will help you battle fatigue and sleep better.


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